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						Axolbio/Dermal Fibroblasts - Huntingtons Disease (HD) Patient/ax3017 (500,000 cells)/1 Ea
					Description:
HumanDermalFibroblastsisolatedfromapatientclinicallydiagnosedwithHuntington"sDisease.Inthesecells,onealleleofthehuntingtingene(HTT)hasanexpansionof56CAGrepeatsandtheotherallelehas15CAGrepeats.
Huntington"sDisease
Huntington"sDiseaseisaneurodegenerativedisorderthataffectsmotorfunctionandco-ordinationandprogressivelyleadstodementiainthelaterstagesofthedisease.Followinganautosomaldominantinheritancepattern,Huntington"sDiseaseischaracterizedbyCytosine-Adenine-Guanine(CAG)repeatswithinthehuntingtingene.Anabnormalformofthehuntingtinproteinisproducedthataffectsthefunctionandhealthofneurons.
TheDermalFibroblastscanbereADIlyculturedintheircurrentstateorreprogrammedtoinducedPluripotentStemCells(iPSCs)andderivedtoavarietyofothercelltypes.AlternativelyyoucanpurchaseHumaniPSC-DerivedNeuralStemCells-Huntington"sDiseasePatient(CAG:56)|ax0212readymade!
HereatAxolBiosciencewecanofferaReprogrammingandDifferentiationservice,aspartofourCustomProjects.WecanprovideyouwithavarietyofcellsthathavebeenderivedfromtheseDermalFibroblasts(Huntington"sDisease)toassistwithyourresearch.
AllofthecellsprovidedaretestedandarenegativeforHIV-1,HIV-2,HepatitisBandHepatitisCasdetectedbyPCR.
Thecellsareconfirmedtobenegativeformycoplasmaandotherdetectablemicrobialcontamination.
ProductSpecification:
| Donorgender | Pleaseinquire | 
| Donorageatsampling | Pleaseinquire | 
| Geneticmodification | None | 
| Size | 500,000cells | 
| Growthproperties | Adherent | 
| Mutation | Onealleleofthehuntingtingene(HTT)hasanexpansionof56CAGrepeatsandtheotherallelehas15CAGrepeats. | 
| Shippingconditions | Dryice | 
| Storageconditions | Liquidnitrogen | 

		